Review
Open access
Aug 2026
The PVR-TIGIT/CD96/CD226 axis: a novel immune checkpoint target in ovarian cancer
The poliovirus receptor (CD155) is an emerging immune checkpoint molecule involved in the suppression of anti-tumor immunity. In ovarian cancer, CD155 is frequently overexpressed and interacts with receptors such as TIGIT, CD96, and CD226 to modulate the activity of T cells, NK cells, and dendritic cells. These interac...
Ming-Yao Huang, Jia-Hui Zhang, Hui-Yan Huang et al.
· Frontiers in Immunology · 0 citations