Open access
Aug 2026
Corynoxine Inhibits Tumor Growth via Targeting NQO1 and Modulating the PTPA–NQO1/PP2A Switch to Activate PP2A
ABSTRACT Corynoxine (Cory) has been reported to suppress lung cancer progression by activating PP2A, but its molecular targets remain unclear. This study shows that Cory exerts anticancer activity across multiple cancer cell lines. Using compound derivatization, affinity‐based protein fishing, LC‐MS/MS, SPR, CETSA, DAR...
Guoqing Hou, Li Lin, Mengjie Xia et al.
· Advancement of science · 0 citations