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Oct 2026

TRIM65 deficiency exacerbates HFD-induced obesity in mice associated with elevated adipose tissue inflammation and lipid accumulation.

Obesity is linked to metabolic and cardiovascular complications, such as atherosclerosis, type 2 diabetes (T2DM), and hypertension. Despite current therapies alleviate certain clinical manifestations, effective disease-modifying targets remain scarce. TRIM65 (tripartite motif-containing 65) has been linked to carcinoge...

Wen-Han Wei, Dan Wang, Xiang-Nuo Han et al. · 0 citations
Open access Sep 2026

Integrated Identification of Macrophage NF-κB, p38 MAPK and AKT1 Signalling as Candidate Targets of Zerumbone in Experimental Periodontitis

Characterised by progressive alveolar bone loss, periodontitis arises from immune dysregulation and is classified as a chronic inflammatory condition. Zerumbone (Zer) has anti-inflammatory properties; however, its mechanism within the periodontal context remains unclear. We investigated the therapeutic effects and pote...

Ting Long, F. Dai, Xiao-Xue Wang et al. · 0 citations

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