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Li-Jun Dong

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Open access Aug 2026

Lactylation-dependent DDX18 nucleolar escape regulates CD44 mRNA stability to drive fibrotic progression in kidney injury

Following acute kidney injury (AKI), a substantial subset of patients experience an irreversible progression to chronic kidney disease (CKD), yet the molecular determinants governing this maladaptive transition remain elusive, and effective clinical interventions are lacking. Here, we identify lactate as a key metaboli...

Li-Jun Dong, Jing-Wen Xie, Meng-Yuan Tao et al. · 0 citations

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