Author

Li-Juan Hu

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Review Open access Sep 2026

Isocitrate Dehydrogenase (IDH) Mutations in Hematological Malignancies: Epidemiology, Mechanisms, and Therapeutic Strategies

Isocitrate dehydrogenase (IDH) mutation is an important molecular abnormality in hematological malignancies, occurring widely in various disease types such as acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and myelodysplastic syndrome (MDS). IDH mutations promote the occurrence and progression of h...

Jin-Kun Xu, H. Bai, Li-Juan Hu · MedComm – Future Medicine · 0 citations

Open access Aug 2026

Bone marrow mesenchymal stem cells are functionally remodeled after complete remission of acute myeloid leukemia

Abstract Background and Objectives Acute myeloid leukemia (AML) is a type of hematological malignancy, induces the normal bone marrow (BM) microenvironment to supporting AML cells. Although previous work revealed that functional remodeling of BM endothelial progenitor cells after complete remission (CR), as another imp...

Zhi-wei Zhang, Zhenkun Wang, Xin-Yan Zhang et al. · Journal of Translational Int... · 0 citations

Open access Jul 2026

Quercetin induces ferroptosis in ovarian cancer by suppressing the NRF2/HO‑1/GPX4 axis and increasing the efficacy of cisplatin.

It is revealed that Quer induces ferroptosis in OC cells at least partially through NRF2/HO-1/GPX4 antioxidant axis suppression and cisplatin effectiveness enhancement and these findings support further evaluation of Quer as a ferroptosis-priming adjunct to platinum-based OC therapy.

Hui Li, Zhaoxuan Liu, Hai-Long Shi et al. · Biochemical Pharmacology · 0 citations