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Author

Li-Jie Yang

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Open access Aug 2026

LncRNA FGD5-AS1 promotes M2 polarization of tumor-associated macrophages to facilitate the malignant phenotype of non-small cell lung cancer cells

Background Tumor-associated macrophages (TAMs) take up a high proportion among immune cells in the tumor microenvironment (TME), and their M2- polarized phenotype has been implicated in promoting non-small cell lung cancer (NSCLC) development. Long non-coding RNA FGD5-AS1 (FGD5-AS1) is up-regulated within multiple tumo...

Jing Wang, Han-Gui Wang, Zheng-Tian Song et al. · 0 citations
Aug 2026

M2-type tumor-associated macrophages depend on the upregulation of LncRNA FGD5-AS1 to facilitate the invasive phenotype of non-small cell lung cancer cells.

M2-TAMs promote the invasive phenotype of NSCLC cells via upregulating the expression of FGD5-AS1 in NSCLC cells through interaction with miR-22-3p and modulating the expression level of miR-22-3p.

Han-Gui Wang, Ning Wang, Li-Jie Yang et al. · 0 citations

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