Author

Li-Hong Hu

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Open access Oct 2026

Camellioside A Engages SIRT3 to Promote FOXO3-PINK1/Parkin Dependent Mitophagy and Attenuate UVB-Induced Skin Photoaging.

Chronic ultraviolet B (UVB) irradiation is a principal driver of skin photoaging, characterized by oxidative stress, mitochondrial dysfunction, fibroblast senescence, and extracellular matrix degradation. Although Camellia chekiangoleosa shows potential for anti-photoaging applications, its bioactive constituents and u...

Hong-Qi Gao, Si-Jia Feng, Jun-Qi Wang et al. · Pharmacological Research · 0 citations

Sep 2026

3-Hydroxydehydroleucodin ameliorates neuroinflammation and ischemic brain injury by blocking the TRIM21-PRDX1 interaction.

3-Hyd is used as a potent neuroprotective agent that markedly reduces the cerebral infarct area and improves neurological deficits in a mouse model of transient middle cerebral artery occlusion and the anti-neuroinflammatory and cerebroprotective effects of 3-Hyd were largely abolished in microglia-specific Prdx1 condi...

Kui Liu, Ling Wang, Zhuo Chen et al. · Acta Pharmacologica Sinica · 0 citations

Aug 2026

Arglabin targets a non-canonical NLRP3/CCR2 axis to suppress MDSC infiltration and potentiates anti-PD-1 immunotherapy in hepatocellular carcinoma.

It is demonstrated that Arg suppresses HCC progression in syngeneic murine models by reducing MDSC infiltration and promoting CD8+ T-cell accumulation, providing a strategy for reversing immunosuppression and potentiating immunotherapy.

Di Kang, Jun-Yuan Duan, Qi Lv et al. · Phytomedicine · 0 citations