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Review Open access Sep 2026

The Lactate–Lactylation Axis as a Metabolic–Epigenetic Framework for Therapeutic Adaptation in Esophageal Squamous Cell Carcinoma

Simple Summary Esophageal squamous cell carcinoma is an aggressive cancer in which treatment failure can reflect adaptation by tumor cells and the surrounding immune environment to chemotherapy and immunotherapy. Lactate, traditionally viewed as a glycolytic byproduct, can also influence gene expression and protein fun...

Jing-Jie Yu, Yi-Yuan Cui, Si-Cong Li et al. · 0 citations
Open access Aug 2026

Network pharmacology and experimental evidence of the anti-colorectal cancer potential of Xian Lian Jie Du formula: quercetin, kaempferol and luteolin jointly inhibit the HIF1A/IL6/TNF oncogenic pathway

A large amount of XLJD and every three flavonoids significantly reduced the mRNA expression of the five hub genes in HT-29 cells; however, the low-concentration group had little to no effect.

Ning Du, L. Ji, Li-Xing Liu et al. · 0 citations

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