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Author

Li Chen

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2 papers indexed here

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Open access Sep 2026

Structural basis for broad orthopoxvirus neutralization by two antibodies targeting distinct L1R epitopes.

The 2022 mpox outbreak highlights the persistent threat posed by the mpox virus (MPXV) and related orthopoxviruses (OPXVs). Yet, approved antibody-based therapeutics for OPXVs are lacking. Here, we present two broadly neutralizing monoclonal antibodies (mAbs), G4 and B9, that target the MPXV M1R protein, homologous to...

Li Chen, Guan-Ying Zhang, Hao-Tian Lin et al. · 0 citations
Open access Oct 2026

A dual-glycoprotein-targeting bispecific nanoantibody confers potent neutralization against Nipah virus.

Nipah virus (NiV) is a biosafety level 4 pathogen that has consistently posed a significant threat to public health. The two envelope proteins on the viral surface, the receptor-binding protein (RBP) and the fusion (F) protein, are the primary targets of neutralizing antibodies. However, the use of antibodies targeting...

Sheng-Dong Wang, Xing-Hai Zhang, Hai-Wei Zhang et al. · 0 citations

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