Open access
Aug 2026
Hydrogel crosslinking mechanisms influence the release and functional delivery of lipid nanoparticles
Investigating the release, stability, cellular uptake, and transfection capability of LNPs released from four hydrogel systems representing distinct crosslinking mechanisms shows that hydrogel composition is a critical determinant of mRNA-LNP release, stability, and functional delivery.
Andreas G. Schreiber, Felix Hauswirth, Leon Reger et al.
· bioRxiv · 0 citations