Open access
Sep 2026
Batten disease protein CLN8 enables a non-canonical phospholipid synthesis pathway
Two studies show that the ER-associated protein CLN8 catalyses the acyl CoA-dependent acylation of glycerophosphoglycerol, producing lysophosphatidylglycerol, which is then converted into BMP, providing insight into CLN8 Batten disease.
Johannes Breithofer, Nermeen Fawzy, C. Zitta et al.
· Nature Cell Biology · 3 citations