Barrier model selection alters apparent diclofenac permeation parameters: a controlled in vitro comparison of Strat-M® and a HaCaT-based epidermal construct
Introduction Synthetic membranes and keratinocyte-based constructs are both used as accessible alternatives to ex vivo skin in in vitro permeation testing (IVPT), but they have not been compared directly for the same marketed products under identical conditions. This pilot study directly compared the synthetic Strat-M®...