Author

Lei Zhang

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Aug 2026

Prevalence of High Tumor Mutational Burden Among Pediatric Patients With Solid Tumors.

High tumor mutational burden (TMB-H), defined as ≥10 non-driver somatic mutations per mega base of genome sequenced (mut/Mb), and high microsatellite instability (MSI-H), which can lead to TMB-H, are both associated with response to the immunotherapy pembrolizumab. Data from the KEYNOTE-158 study demonstrated that the...

Wen-Jun Zhong, E. Dettman, Lei Zhang et al. · Pediatric Hematology & Oncol... · 0 citations

Open access Jan 2026

Integrated Bulk and Single‐Cell Transcriptomic Analyses Identify a Five‐Gene Signature Associated With Prognosis and the Tumor Microenvironment in Epstein–Barr Virus–Associated Gastric Cancer

A five‐gene signature with strong diagnostic value and biologically meaningful prognostic relevance in EBVaGC is identified, highlighting fibroblast‐ and B‐cell‐associated microenvironmental programs in aggressive disease.

Luyu Jin, Man Jiang, Yu-Long Pan et al. · Genetics Research · 0 citations