Sono-Triggered In Situ Vaccine via a Chlorin-Based Small Molecule Sensitizer for Systemic Cancer Therapy.
Unimolecule-mediated sonodynamic therapy (SDT) offers a promising approach to combat tumors systemically by enabling synergistic sono-triggered cytotoxicity and in situ vaccine-like effects within tumors. Although chlorin-based sensitizers have achieved clinical success in phototherapy, their translation to SDT has bee...