Author

Lei Wang

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Open access Oct 2026

Discovery and Optimization of the Novel Immunotoxins Targeting TROP2 for Cancer Therapy

Background: Trophoblast cell surface antigen 2 (TROP2) is widely overexpressed in epithelial cancers and associated with poor prognosis, representing an attractive target for cancer treatment. Recent clinical studies reported favorable outcomes of TROP2-targeting antibody–drug conjugates. However, heterogeneity of huma...

Jun-Yan Li, Tanja Poredoš, Shu-Yi Xu et al. · Pharmaceuticals · 0 citations

Open access Aug 2026

A CXCR4/PD-L1 Bispecific Nanobody Engineered for Tumor Microenvironment Retention Mediates Sustained Synergy with Chemotherapy via Remodeling Immunity in TNBC

These findings reveal that dual blockade of PD-L1 and CXCR4 acts synergistically with chemotherapy by triggering tumor cell apoptotic effects and reversing the immunosuppressive microenvironment, thereby emerging as a promising therapeutic strategy for TNBC.

Shuyi Xu, Hai Hu, Yi-Fan Li et al. · Pharmaceuticals · 0 citations