Conventional single-target drugs frequently suffer from limited efficacy and drug resistance. Here, we report an amphiphilic peptide dendrimer that integrates intrinsic bioactivity and nanocarrier functions, establishing a novel “drug-bioactive carrier” paradigm for multi-target cancer therapy. Using reverse molecula...
Yuan-Zheng Huang, Chong-Qing Pan, Bao-Ping Lian et al.· Journal of Medicinal Chemist...· 0 citations
These studies highlight the expanding scope of proximity-induced phosphorylation control, while emphasizing that broader application will depend on improved molecular design and a clearer understanding of proximity-driven mechanisms.
Yuxin Xia, Daichao Zhai, Qi-Dong You et al.· RSC Medicinal Chemistry· 0 citations
Five synergistic tactics to boost covalent inhibitor selectivity are summarized, and these innovations validate kinact/Ki as a unified rule balancing efficacy and selectivity.
Shang-Jun Bai, Meng-Han Gao, Qi-Dong You et al.· European journal of medicina...· 0 citations
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