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Author

Lei Mou

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Open access Aug 2026

From local control to systemic management: radiotherapy and sequential methotrexate therapy in an adult BRAF-negative hypothalamic-pituitary Langerhans cell histiocytosis – a case report with 15-month follow-up

This case illustrates that involved-field IMRT can achieve durable local control of HPR-LCH even in BRAF V600E-negative cases, but local control does not equate to systemic cure; close surveillance for extracranial progression is essential, and timely systemic chemotherapy is critical for managing multisystem disease.

Chi Feng, Zhiming Chen, Liang Chen et al. · 0 citations
Review Dec 1999

Medical Image Analysis

Since the discovery of the X-ray radiation by Wilhelm Conrad Roentgen in 1895, the field of medical imaging has developed into a huge scientific discipline. The analysis of patient data acquired by current image modalities, such as computerized tomography (CT), magnetic resonance tomography (MRT), positron emission tom...

Lei Mou, Yitian Zhao, H. Fu et al. · 397 citations · ⚡29
Review Dec 1999

Medical Image Analysis

Since the discovery of the X-ray radiation by Wilhelm Conrad Roentgen in 1895, the field of medical imaging has developed into a huge scientific discipline. The analysis of patient data acquired by current image modalities, such as computerized tomography (CT), magnetic resonance tomography (MRT), positron emission tom...

Lei Mou, Yitian Zhao, H. Fu et al. · 398 citations · ⚡29

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