Daxx depletion remodels silent rDNA chromatin and increases UBF-bound transcriptional potential.
Ribosomal DNA (rDNA) repeats are regulated by DNA methylation, histone modifications, nucleosome occupancy, and nucleolar organization. Here, we used a data-driven ChIP-seq background-subtraction strategy to re-examine epigenetic profiles at rDNA repeats and found that Daxx and Atrx are preferentially enriched in the p...