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A comprehensive transcriptomic and chromatin accessibility atlas of 8 brain regions of 23 female cynomolgus macaques spanning the adult lifespan, including exceptionally old individuals establishes a foundational framework for understanding the cellular and regulatory architecture of primate brain aging and its links to disease.
Together, gene expression-defined cortical layers (GD-Ls) provide an objective and reproducible tool for standardized cortical mapping and for identifying early pathological signatures in the human brain.
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