Lei-Fang Sun

The pseudogene derived transcript SUZ12P activates SUZ12 transcription through an RB1-E2F1 regulatory axis in lung cancer

Genome-wide studies have identified thousands of pseudogenes in the human genome, many of which are now recognized as functional regulators rather than inert genomic relics. Increasing evidence indicates that pseudogene-derived transcripts play critical roles in cancer; however, the role and mechanism of pseudoge...