Author

Lei Fang

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Review Open access Aug 2026

Body roundness index, frailty, and prevalent self-reported stroke: An exploratory cross-sectional decomposition analysis.

Introduction Prior NHANES studies have reported nonlinear associations of the body roundness index (BRI) with prevalent stroke and frailty. The authors updated these observations using NHANES 1999-2023 and examined the additional contribution of frailty to the BRI-prevalent self-reported stroke association. Method Th...

Ze-Kai Hu, Jie Zhuang, Jin-Yan Wang et al. · Annals of the Academy of Med... · 1 citation

Open access Sep 2026

Betulonic acid, a bioactive triterpenoid from Celastrus orbiculatus extract, reverses chemoresistance in gastric cancer via CD44v6-mediated actin cytoskeleton remodeling.

Chemoresistance remains a major obstacle limiting the therapeutic efficacy of gastric cancer treatments, and cytoskeleton remodeling together with the abnormal membrane localization of drug efflux proteins may contribute to resistance phenotypes. This study aimed to investigate the role of CD44v6 in gastric cancer chem...

Ze-Wen Chu, Miao Zhu, Yuan Luo et al. · Phytomedicine · 0 citations

Review Open access Aug 2026

Mitochondrial Inflammation and Muscle Aging: Targeting the Inflammatory Microenvironment in Sarcopenic Muscle.

This review synthesizes current evidence on the molecular mechanisms underlying inflammation-driven sarcopenia and outlines potential therapeutic strategies targeting the inflammatory microenvironment, offering insights for future research and clinical management.

Xuesong Wang, Shannah Erasmus, Zewen Chu et al. · Aging and Disease · 0 citations