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Review Open access Oct 2026

Aberrant NRF2-Dependent Cytoprotection Subverts Stress Homeostasis and Promotes Tumor Progression

Nuclear factor erythroid 2-related factor 2 (NRF2) coordinates antioxidant defense, metabolism, iron homeostasis, and proteostasis to support cellular adaptation to stress. Kelch-like ECH-associated protein 1 (KEAP1)-Cullin 3 (CUL3) continuously targets NRF2 for proteasomal degradation. Oxidative or electrophilic stres...

Gao-Qing Feng, Yu-Hong Yang, Hua-Hua Wang et al. · 0 citations
Open access Sep 2026

Pharmacologically Targeting DHODH-Dependent Pyrimidine Metabolism with HSA-Conjugated BRQ Suppresses Leukemogenesis

Background: Metabolic reprogramming is a hallmark of acute myeloid leukemia (AML) and provides a rich source of therapeutic vulnerabilities. Among these, de novo pyrimidine biosynthesis has emerged as an important metabolic dependency, yet its contribution to AML progression remains incompletely defined. DHODH, a rate-...

Xiao-Xu Zhang, Chang-Hao Tian, Yang Ding et al. · 0 citations

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