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Author

Lei Chen

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Open access Aug 2026

UBA1 enhances phagocytosis by suppressing CD47 expression in small cell lung cancer

Introduction Small cell lung cancer (SCLC) exhibits a limited overall response rate to immunotherapy, largely due to its highly immunosuppressive microenvironment. CD47, an innate immune checkpoint frequently overexpressed on SCLC cells, contributes to immune evasion by inhibiting macrophage-mediated phagocytosis. Here...

Dong-Yu Li, Na Li, Yiqiang Liu et al. · 0 citations
Open access Jul 2026

Upregulation of macrophage UPP1 promotes lung adenocarcinoma metastasis through an mtROS-cGAS-NLRP3 inflammasome axis.

A macrophage-specific immunometabolic circuit in which UPP1-driven mitochondrial stress activates the mtROS-cGAS-NLRP3 axis, promoting IL-1β-dependent macrophage-tumor crosstalk and metastatic progression is identified.

Mingtao Feng, Chao Gao, Yue-fei Yang et al. · 0 citations

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