AKT1-dependent phosphorylation of PRMT5 prevents Siah1a-mediated CtBP1/2 ubiquitination to contribute to abdominal aortic aneurysm progression.
AIMS Abdominal aortic aneurysm (AAA) is a progressive vascular disease characterized by chronic inflammation and extracellular matrix (ECM) degradation. Although C-terminal binding protein 1 and 2 (CtBP1/2)-mediated transcriptional activation has been implicated in AAA progression, the upstream mechanisms regulating Ct...