Leendert J. Cloete

FuncSeek: Multi-PLM contrastive learning for protein functional similarity search

FuncSeek is described, a contrastive learning model which utilizes three diverse, complementary PLMs: ESM2 (to model evolutionary co-variation), ProstT5 (for bilingual sequence and structure embeddings), and ProteinBERT (for functional semantic similarities) that each capture a different aspect of protein biology: evolutionary patterns, three-dimensional shape, and functional context.