Author

Le Yang

3 papers indexed here

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Open access Oct 2026

Gut microbiota-derived 7-KDCA protects against diabetic sarcopenia by interrupting the NLRP1-ferroptosis crosstalk in myotubes

Type 2 diabetes mellitus (T2DM) accompanied by sarcopenia is an emerging clinical challenge in aging populations, yet the treatment options remain scarce. Recent advances in metabolomics have revealed that gut microbial bile acids function as essential players in muscle mass and function. The aim of the present stu...

Qing-Bo Lu, Chen-Yang Zhao, Le Yang et al. · Cell Death Discovery · 0 citations

Open access Jan 2026

Haikun Shenxi Capsule Alleviates Renal Fibrosis in CKD Mice by Targeting the METTL3/IGF2BP3‐Mediated m6A Modification of NKD2

Background Renal fibrosis is a central pathological process in chronic kidney disease (CKD). Although Haikun Shenxi Capsule (HKSX) has shown clinical efficacy in CKD, its precise molecular targets and mechanisms remain unclear. Objective This study aims to determine whether HKSX exerts antifibrotic effects in CKD by mo...

Mingjia Gu, Le Yang, An-Jing Xu et al. · Mediators of Inflammation · 0 citations

Open access Sep 2026

Hepatocyte SLC31A1-dependent copper accumulation contributes to hepatic glucose and lipid metabolic disturbances through AMPKα1 inactivation

Hepatic insulin resistance and fat accumulation are common features of metabolic syndrome, obesity and type 2 diabetes (T2D). However, whether the copper importer SLC31A1 has a role in diabetes-associated hepatic metabolic disorders remains unknown. Thus, we studied the role of hepatocyte SLC31A1 in HFD/STZ-induced T2D...

Yin-Qin Cheng, Min Wei, Le Yang et al. · Biochemistry and Biophysics... · 0 citations