Author

Letong Xu

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Open access Sep 2026

Characterization of hypothetical proteins reveals function modules and virulence factors in Pseudomonas aeruginosa

Hypothetical proteins (HPs), known as biological dark matter, are genetic sequences of which the biological functions and regulatory processes remain largely unclear. In Pseudomonas aeruginosa, HPs account for 36.4% of all coding genes, representing a significant gap in understanding their functions and contribution to...

Chun-Yan Yao, Bei-Fang Lu, Yi-Qing Ding et al. · Nature Communications · 0 citations

Open access Aug 2026

Thirteen‐year genomic analysis (2010–2022) reveals high‐risk ICU Pseudomonas aeruginosa in China

Findings underscore a qualitative distinction in ICU P. aeruginosa: their dominance and persistence stem from highly adapted clones, robust anti‐phage defenses, rapid plasmid‐mediated AMR acquisition, and clinically selected prophage‐borne AMR.

Jia-Dai Huang, Kai-Chao Chen, Miaomiao Xie et al. · mLife · 0 citations

Open access Aug 2026

Quantitative single-base m6A profiling reveals dynamic reprogramming, evolutionary conservation and transcriptional regulation in bacteria.

GLORI sequencing is applied to generate single-base resolution transcriptome-wide m6A maps in seven bacterial species to provide a quantitative atlas of bacterial m6A and establish a foundation for understanding its regulatory and evolutionary roles.

Youyue Li, Letong Xu, Na Liu et al. · Cell Reports · 0 citations