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Le-Tong Huang

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Review Open access Oct 2026

From Mechanistic Models to AI Synergy: A Roadmap for Predictive and Personalized Biology

Simple Summary Biology currently runs on two modeling traditions. Mechanistic models write down the processes a biologist believes are at work, so their variables and parameters carry meaning, but they are slow to build and hard to fit to the volume of data that modern experiments produce. Deep learning finds patterns...

Le-Tong Huang, Hong-Qin Sun, Yi Huang et al. · 0 citations
Review Open access Sep 2026

Non-Coding RNAs in Oral Diseases: From Pathogenesis to Clinical Translation

Oral diseases represent a major global health burden, and non-coding RNAs (ncRNAs) have emerged as pivotal regulators in their pathogenesis, offering new avenues for diagnosis and therapy. This review synthesizes current knowledge on ncRNAs—including miRNAs, lncRNAs, and circRNAs—across a spectrum of oral conditions, e...

Le-Tong Huang, Hai-Long Zhang, Yi Huang et al. · 0 citations
Review Aug 2026

Thiamine diphosphate-dependent enzymes: mechanistic principles, stereoselective C-C bond formation, and synthetic biocatalytic applications.

This review systematically elucidates the structural characteristics, classification, and diverse reactions catalyzed by ThDP-dependent enzymes, with a primary focus on their potential for stereoselective C-C bond formation and cleavage.

Jin-Xi Huang, Le-Tong Huang, Xuemei Wang et al. · 0 citations
Review Open access Aug 2026

Structural Variation and Its Roles in Plant Genomes

Together, these advances establish SV-centered genomics as a critical framework for understanding plant genome evolution and accelerating precision crop improvement.

Ru-Yi Liu, Le-Tong Huang, Jing-Ru Mu et al. · 0 citations

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