Sep 2026
An Enzyme from a Single P450 Monooxygenase Clade Orchestrates Six‑Electron Oxidation for Cyclopeptide Modification
This study characterizes IlaL, a cytochrome P450 monooxygenase from Streptomyces atratus, which catalyzes a six‑electron methyl‑to‑carboxylic acid conversion during the biosynthesis of the potent antimycobacterial cyclopeptide ilamycins.
Ming Peng, Qiao-Ling Wu, Ying-Ying Chen et al.
· ACS Catalysis · 0 citations