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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Layne Pruitt

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2 papers indexed here

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Aug 2026

Antigen avidity potentiates the durability of the vaccine immune response.

The protective benefits of vaccination can critically depend on the durability of the corresponding immune response. However, the factors influencing vaccine durability are poorly understood. Here, we tested whether antigen avidity (i.e., cumulative multivalent binding strength) affected the durability, magnitude, and...

Nicole G Weidner, Mauricio V. Padilla, Layne Pruitt et al. · 3 citations
Open access Aug 2026

Immunization with mosaic nanoparticles reveals that antigen avidity shapes the clonal hierarchy of the B cell response.

Vaccination with real-world complex antigens often elicits a hierarchical immune response to different epitopes. This immunodominance is a major obstacle in vaccine design because nonprotective epitopes often divert the immune response away from protective epitopes. We posited that B cell epitope avidity (i.e., total m...

Mauricio V. Padilla, Nicole G Weidner, Layne Pruitt et al. · 3 citations

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