Quality-by-Design-Guided Reactive Oxygen Species-Responsive Antimicrobial Nanotheranostics for Biofilm Eradication: A Translational Perspective.
OBJECTIVE Biofilm-associated infections remain a major therapeutic challenge due to extracellular polymeric substance (EPS) barriers, metabolic heterogeneity, and hypoxic microenvironments that limit antimicrobial penetration and efficacy. Antimicrobial nanotheranostics have emerged as multifunctional platforms that co...