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Author

Laurie Clauzon

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Open access Oct 2026

Targeting CD44v6 and PI3K disrupts HGF-driven reprogramming of colorectal cancer stem cells

Therapeutic adaptive responses and secondary resistance represent major obstacles to effective colorectal cancer treatment. These dynamic adaptations arise within a permissive tumor microenvironment that sustains cancer cell survival, epithelial-mesenchymal plasticity and the outgrowth of drug-tolerant clones, ultima...

Kimiya Shams, Francesco Verona, Ornella Roberta Brancato et al. · 0 citations
Aug 2026

P1.105. Epithelial–Mesenchymal Plasticity Underlies Adaptive Resistance to FLOT Chemotherapy in Esophageal Adenocarcinoma

Findings suggest a dynamic, reversible model of chemoresistance driven by EMP rather than fixed cell identity, which may support the development of treatment strategies that limit resistance and improve patient response to perioperative chemotherapy.

Laurie Clauzon, Kimiya Shams, Roberta Drago et al. · 0 citations

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