Author

Laurent Briollais

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Preprint Sep 2026

Risk prediction models for breast cancer integrating family history of breast cancer and prophylactic interventions

Breast cancer risk assessment and prediction models are very important tools for the clinical management of healthy women carrying pathogenic variants in known cancer genes. We propose in this paper a comprehensive prediction model for the personalized clinical management of women with pathogenic variants in {\it BRCA1...

Siriac Seboka, Laurent Briollais, Yun-Hee Choi et al. · 0 citations

Preprint Aug 2026

Correlated frailty model for analysis of genetic association in family studies

Family-based study designs allow the investigation of gene mutation effects on a disease risk by considering related family members. Some methods have been developed for testing sets of genetic variants in family studies but only very few can handle right-censored time-to-event data. We propose here a correlated frailt...

Agnieszka Król, Virginie Rondeau, Yun-Hee Choi et al. · 0 citations