Laurence W. Fitzpatrick

Adaptive dark-field interferometric scattering microscopy for label-free imaging of nanoscale systems

Interferometric scattering microscopy (iSCAT) enables label-free detection of nanoscale entities by interfering weak scattered light with a reference field, yielding high sensitivity for single-particle mass photometry, three-dimensional tracking, and kinetic studies of proteins, viruses, and nanoparticles—dynamics elu...