Lauren Fogel

Atherosclerosis destabilizes regulatory T cells (Tregs) resulting in multiple families of exTregs

Distinct Treg subsets in human peripheral blood are defined by unique transcriptomic signatures 2252633

Regulatory CD4+ T cells (Tregs) are critical for maintaining tolerance to self. Chronic inflammation can cause Treg instability which is defined by loss of CD25 and the lineage-defining transcription factor FOXP3, resulting in exTreg cells. To better understand the factors driving Treg to exTreg conversion...

Regulatory T cells turn into multiple pro-inflammatory effector T cells in Mice with Atherosclerosis 2247491

Atherosclerosis is an immune-mediated disease in which regulatory T cells (Tregs) can lose lineage stability and convert into pro-inflammatory effector states (“exTregs”) that may accelerate plaque progression. However, the diversity, lineage relationships, and pathogenic roles of exTreg subsets in cardiovascular...