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Author

Laura Zarbo

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Review Open access Aug 2026

Targeting Human Immunodeficiency Virus Integrase Beyond the Active Site: The Discovery and Development of Allosteric Integrase Inhibitors

This review focuses on ALLINIs, providing a comprehensive overview of major drug discovery efforts devoted to this field, with an emphasis on the medicinal chemistry and structural biology findings that have revealed unprecedented opportunities for developing innovative and effective anti‐HIV drugs.

Francesco Saccoliti, E. Patacchini, Emanuele Cara et al. · 0 citations
Open access Aug 2026

Exploring the Pyrimidine Scaffold for the Development of SARS-CoV-2 Mpro Inhibitors.

New SARS-CoV-2 Mpro small-molecule inhibitors endowed with a pyrimidine scaffold are designed and synthesized and the mechanism of action of the most promising compound was elucidated.

Salvatore Nieddu, Giuseppe Ruggieri, Riccardo De Santis et al. · 0 citations

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