Open access
Sep 2026
Decoding the Cellular Response to Methylthioadenosine Uncovers Novel Targets for Chronic Liver Disease
Progressive familial intrahepatic cholestasis type 3 (PFIC3), caused by MDR3 deficiency (MDR2 in mice), is a lethal pediatric liver disease characterized by early-onset persistent cholestasis, progressive fibrosis, cirrhosis, and eventual liver failure. MDR3 is a phosphatidylcholine transporter located in the canalicul...
Irene Blázquez-García, Laura Guerrero, M. D. S. Tai et al.
· Cells · 0 citations