Author

Laura A. Cooney

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Open access Sep 2026

IL-2 mutein selectively expands thymic memory Tregs with increased transendocytosis activity in healthy participants.

Tregs play an essential role in immune tolerance, and Treg-promoting therapies are in development for the treatment of many inflammatory disorders. Interleukin-2 (IL-2)-based therapies increase Treg frequency, but little is known about impacts on Treg heterogeneity and function. We extended analyses of an IL-2 mutein (...

Laura A. Cooney, M. Fahning, Liliane Khoryati et al. · JCI Insight · 0 citations

Open access Sep 2026

Autologous Hematopoietic Transplantation Reduces Brain Inflammatory and Axoglial Damage Biomarkers in Multiple Sclerosis

The hypothesis that AHSCT results in long-lasting reductions in inflammatory cytokines, chemokines, and axoglial damage markers, consistent with persistent disease quiescence is confirmed.

Laura A. Cooney, N. Lim, Kristina M. Harris et al. · Neurology(R) neuroimmunology... · 0 citations

Open access Aug 2026

Abatacept Reduces CD319+ (SLAMF7) Cytotoxic T Cells and Cytokine Production in Systemic Sclerosis.

Abatacept selectively modulates CD319/SLAMF7-expressing cytotoxic T cells and suppresses associated pro-fibrotic and pro-inflammatory cytokines, particularly in the fibroproliferative subtype, where CD319+ T cell reductions correlate with clinical improvement.

Mikel Gurrea-Rubio, Laura A. Cooney, Kohei Maeda et al. · Arthritis & Rheumatology · 0 citations