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The neonatal heart experiences rapid metabolic growth after birth to meet increasing energetic and biosynthetic demands. How mitochondrial cofactor availability limits this transition remains unclear. Here, we demonstrate that mitochondrial S-adenosylmethionine (mitoSAM) import through SLC25A26 becomes limiting shortly...
Inflammation plays a central role in the pathophysiology of heart failure (HF), and contributes to disease progression, morbidity and mortality. However, the relationships between inflammatory cytokines and different HF subtypes are complex, heterogeneous and bidirectional. In this review, we examine inflammatory pathw...
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