Open access
Oct 2026
Latexin deletion in the bone marrow niche suppresses leukemia via LIFR downregulation and immune activation.
Acute myeloid leukemia (AML) is the most common adult leukemia diagnosis. Bone marrow (BM) niche significantly influences the initiation and progression of AML. However, our knowledge about the effect of leukemic niche on leukemia stem cells (LSC) and leukemogenesis is limited. In this study, we identified an extrinsic...
Cui-Ping Zhang, Xia Yao, Pin-Pin Sui et al.
· JCI Insight · 0 citations