Dynamic microenvironments for bone organoids: spatiotemporal regulation of angiogenic-osteogenic coupling through advanced hydrogel design
Bone organoids are promising platforms for studying skeletal development, disease and regeneration, but their broader application is limited by inadequate vascularization and the difficulty of recapitulating the evolving native bone microenvironment. In vivo, angiogenesis and osteogenesis are tightly coupled processes...