Open access
Sep 2026
Osteoimmune senescence in aging bone: from inflammaging dogma to cell-type-specific therapeutic windows
Aging-related bone diseases are often interpreted through hormonal decline, defective remodeling, and chronic low-grade inflammation, yet these accounts do not fully capture the cellular, spatial, and temporal heterogeneity of skeletal aging. Bone is an immune-active organ sustained by coordinated signaling among skele...
Lan Zhang, Yao Yao, Jin-Xu Chen
· Frontiers in Immunology · 0 citations