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Author

Lan-Qing Cao

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2 papers indexed here

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Aug 2026

Ti6Al4V/Xenogeneic bone composite promotes osseointegration by recapitulating the osteogenic microenvironment

Ti6Al4V implants are used to repair critical-sized bone defects, but their bioinert surfaces often cause insufficient early osteogenic stimulation, potentially leading to compromised long-term fixation. The osteogenic microenvironment is vital for osseointegration between the host bone and the implant and influences lo...

Xiang-Ping Yue, Wen-Bo Yang, Hao Chen et al. · 0 citations
Review Open access Sep 2026

Beyond the tumor microenvironment: a hierarchical immune-circuit model of immune checkpoint blockade resistance

Immune checkpoint blockade (ICB) produces durable tumor control in a subset of patients, yet resistance is usually interpreted through tumor-intrinsic lesions or suppression within the tumor microenvironment (TME). We propose that ICB resistance can also be organized as failure of a multiscale antitumor immune circuit...

Xue Zhao, Han Wang, Ya-Nan Liu et al. · 0 citations

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