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A novel conditioning regimen incorporating low-dose cyclophosphamide and thiotepa for haploidentical hematopoietic stem cell transplantation in pediatric patients with severe aplastic anemia at high risk of cardiotoxicity.
BACKGROUND High-dose cyclophosphamide (Cy)-related cardiotoxicity (CT) during transplant conditioning in patients with severe aplastic anemia (SAA) is a life-threatening complication. OBJECTIVE To evaluate the efficacy and safety of a modified conditioning regimen to reduce CT in pediatric SAA. METHODS We conducted...