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Myocardial Fibrosis in Pediatric Heart Disease: Mechanisms, Imaging Biomarkers, Clinical Consequences, and Emerging Antifibrotic Therapies.
Myocardial fibrosis is increasingly recognized as a central determinant of adverse cardiac remodeling and long-term cardiovascular outcomes in children with congenital and acquired heart disease. Once considered an irreversible consequence of chronic myocardial injury, fibrosis is now understood to represent a dynamic...
Left Atrial Myopathy Across the Spectrum of Pediatric Heart Disease: Imaging, Mechanobiology, and Clinical Consequences.
Current understanding of left atrial mechanobiology, multimodality imaging assessment, and clinical implications of LA dysfunction in pediatric heart disease are summarized.