Review
Open access
Oct 2026
O-linked β-N-acetylglucosamine homeostasis in brain health and disease: From physiology to neurodevelopmental and neurodegenerative disorders.
ABSTRACT Protein O-GlcNAcylation is a dynamic and reversible post-translational modification that functions as a central nutrient-sensing mechanism linking cellular metabolism to protein function. Controlled by the opposing activities of O-linked β-N-acetylglucosamine transferase and O-GlcNAcase, O-GlcNAcylation regula...
F. Di Domenico, Laiba Ashraf, Chad Slawson et al.
· Neural Regeneration Research · 0 citations