Background: Stroke remains a leading cause of mortality and long-term disability worldwide, with high residual vascular risk among survivors despite optimal secondary prevention. The contribution of inherited polygenic risk to this residual vulnerability remains unclear. Methods: We analyzed 2,701 stroke survivors (mea...
N. Bragazzi, L. Zhang, M. Omarov et al.· medRxiv· 0 citations
Together, AtherOMICS enables multimodal characterization of human atherosclerosis aiming for the discovery of athero-specific drug targets, molecular signatures of atheroprogression, and noninvasive biomarkers of plaque vulnerability.
L. Živković, R. Batool, J. Louma et al.· Science Advances· 0 citations
Deep proteomic profiling of human carotid plaques identifies molecular signatures of symptomatic atherosclerosis that extend beyond conventional histopathology, which implicate neutrophil activation and inflammatory signaling pathways as key determinants of plaque vulnerability.
L. Zhang, L. Živković, A. Ray et al.· medRxiv· 0 citations
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