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Author

L. Wain

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4 papers indexed here

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Open access Oct 2026

Identifying fibrotic interstitial lung disease risk in COPD, asthma and heart failure

Fibrotic interstitial lung disease (fILD) is often diagnosed late and can be difficult to recognise in people with common respiratory or cardiac long-term conditions. We examined whether baseline routine blood-test profiles and leucocyte telomere length (LTL) identified groups at higher risk of subsequent hospital-...

G. Lough, L. Wain, A. Meffen et al. · 0 citations
Open access Sep 2026

Genome-wide association studies to identify shared and distinct mechanisms of fibrosis across 12 organ systems

Evidence of shared genetic associations for fibrosis across organs is found, both at individual genetic loci and genome-wide, which highlights specific genes that may contribute to fibrosis across organs and diseases, which may facilitate the development of new therapies.

Ebrima Joof, T. Hernández-Beeftink, G. Parcesepe et al. · 0 citations
Open access Sep 2026

Proteome-wide Mendelian randomisation of lung function to identify potential therapeutic targets for respiratory disease

This work identifies proteins that are potentially therapeutic targets for respiratory disease, and which warrant follow-up for utility and safety, and adds to the literature identifying surfactant protein D as a candidate, yet predicts that integrin subunit alpha V (ITGAV) inhibition could impair some lung function me...

Jing Chen, N. Shrine, Kayesha Coley et al. · 0 citations

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