Although amyotrophic lateral sclerosis (ALS) has traditionally been viewed as a motor neuron-centered disease manifesting by muscle wasting and weakness, growing evidence indicates that disease progression is strongly influenced by interactions between motor neurons and surrounding glial cells. Astrocytes are major r...
W. S. Kim, H. Timmins, L. Van Den Bosch et al.· Cellular and molecular neuro...· 0 citations
Amyotrophic lateral sclerosis (ALS) is a severe disease that causes thousands of deaths annually. Current treatments are either limited in effectiveness or not broadly applicable. To discover new options, we conducted a genetics-based screen to identify drugs that could be repurposed for ALS. We analyzed genome-wid...
S. Saez-Atienzar, Luis A. Rojas-Colón, Ruth Chia et al.· npj Digital Medicine· 0 citations
The findings identify the endocannabinoid system as an integral component of ALS muscle pathology and support skeletal muscle lipid signalling as a potentially relevant early target for adjunctive therapeutic strategies.
Sebastiaan Dalle, Kaat Vanderbeke, T. Burg et al.· Journal of Cachexia, Sarcope...· 0 citations
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