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Author

Lorenz Studer

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Open access Oct 2026

Developmental rewiring of EHMT1 function during human cortical neurogenesis

Ubiquitously expressed chromatin regulators orchestrate cell-type-specific gene expression programs, yet how they acquire distinct regulatory functions during development remains fundamentally unresolved1,2. Using temporally controlled protein depletion during human cortical neurogenesis in vitro, we show that the auti...

K. Kasliwal, K. Chatterjee, V. Bocchi et al. · 0 citations
Open access Sep 2026

Decoding subtype development and function in human pluripotent stem cell-derived midbrain dopaminergic neurons

Midbrain dopaminergic (mDA) neurons comprise molecularly and functionally distinct subtypes with differential vulnerability in neurodegenerative and psychiatric disorders. However, the mechanisms specifying subtype identity remain poorly understood, and protocols for the selective derivation of human mDA subtypes are l...

Dong-He Yang, Sejoon Choi, Jing-Hua Piao et al. · 0 citations
Review Aug 2026

Induced pluripotent stem cells from discovery to translation

This Review evaluates the technological and translational trajectories that have defined the iPSC era and analyzes the operational barriers to therapeutic development, envisioning a paradigm shift in which iPSC-derived interventions transition from bespoke experimental models toward standardized, engineered biological...

Jaecheol Lee, Todd J. Herron, L. Studer et al. · 0 citations

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